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KMID : 0388120140230030150
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Journal of Korean Society for the Study of Obesity
2014 Volume.23 No. 3 p.150 ~ p.155
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Exosomes and Microvesicles as Biomarkers in Metabolic Diseases
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Lee Seong-Kyu
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Abstract
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Currently used biomarkers in metabolic diseases are neither sufficient for monitoring the stage of disease development nor for monitoring differences among patients with different underlying pathogenetic pathways and pathogenesis. Exosomes and microvesicles, which are released from a wide variety of tissues, cells and blood cells in response to normal or stressed state, and under pathogenic conditions, contain various proteins, mRNAs, miRNAs and etc. that reflect the diverse functional and dysfunctional states of the releasing cells and tissues. Therefore, exosomes and microvesicles could be the next potential new biomarkers that could help predict, diagnose, treat and monitor prognosis of metabolic diseases as in obesity. Exosomes and microvesicles may overcome limitations of current biomarkers once their characteristics are clarified and methods for easier detection are developed.
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KEYWORD
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Exosomes, Microvesicles, Biomarkers, Metabolic diseases
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